Wall Street Week Ahead: Attention turns to financial earnings

NEW YORK (Reuters) - After over a month of watching Capitol Hill and Pennsylvania Avenue, Wall Street can get back to what it knows best: Wall Street.

The first full week of earnings season is dominated by the financial sector - big investment banks and commercial banks - just as retail investors, free from the "fiscal cliff" worries, have started to get back into the markets.

Equities have risen in the new year, rallying after the initial resolution of the fiscal cliff in Washington on January 2. The S&P 500 on Friday closed its second straight week of gains, leaving it just fractionally off a five-year closing high hit on Thursday.

An array of financial companies - including Goldman Sachs and JPMorgan Chase - will report on Wednesday. Bank of America and Citigroup will join on Thursday.

"The banks have a read on the economy, on the health of consumers, on the health of demand," said Quincy Krosby, market strategist at Prudential Financial in Newark, New Jersey.

"What we're looking for is demand. Demand from small business owners, from consumers."

EARNINGS AND ECONOMIC EXPECTATIONS

Investors were greeted with a slightly better-than-anticipated first week of earnings, but expectations were low and just a few companies reported results.

Fourth quarter earnings and revenues for S&P 500 companies are both expected to have grown by 1.9 percent in the past quarter, according to Thomson Reuters I/B/E/S.

Few large corporations have reported, with Wells Fargo the first bank out of the gate on Friday, posting a record profit. The bank, however, made fewer mortgage loans than in the third quarter and its shares were down 0.8 percent for the day.

The KBW bank index <.bkx>, a gauge of U.S. bank stocks, is up about 30 percent from a low hit in June, rising in six of the last eight months, including January.

Investors will continue to watch earnings on Friday, as General Electric will round out the week after Intel's report on Thursday.

HOUSING, INDUSTRIAL DATA ON TAP

Next week will also feature the release of a wide range of economic data.

Tuesday will see the release of retail sales numbers and the Empire State manufacturing index, followed by CPI data on Wednesday.

Investors and analysts will also focus on the housing starts numbers and the Philadelphia Federal Reserve factory activity index on Thursday. The Thomson Reuters/University of Michigan consumer sentiment numbers are due on Friday.

Jim Paulsen, chief investment officer at Wells Capital Management in Minneapolis, said he expected to see housing numbers continue to climb.

"They won't be that surprising if they're good, they'll be rather eye-catching if they're not good," he said. "The underlying drive of the markets, I think, is economic data. That's been the catalyst."

POLITICAL ANXIETY

Worries about the protracted fiscal cliff negotiations drove the markets in the weeks before the ultimate January 2 resolution, but fear of the debt ceiling fight has yet to command investors' attention to the same extent.

The agreement was likely part of the reason for a rebound in flows to stocks. U.S.-based stock mutual funds gained $7.53 billion after the cliff resolution in the week ending January 9, the most in a week since May 2001, according to Thomson Reuters' Lipper.

Markets are unlikely to move on debt ceiling news unless prominent lawmakers signal that they are taking a surprising position in the debate.

The deal in Washington to avert the cliff set up another debt battle, which will play out in coming months alongside spending debates. But this alarm has been sounded before.

"The market will turn the corner on it when the debate heats up," Prudential Financial's Krosby said.

The CBOE Volatility index <.vix> a gauge of traders' anxiety, is off more than 25 percent so far this month and it recently hit its lowest since June 2007, before the recession began.

"The market doesn't react to the same news twice. It will have to be more brutal than the fiscal cliff," Krosby said. "The market has been conditioned that, at the end, they come up with an agreement."

(Reporting by Gabriel Debenedetti; editing by Rodrigo Campos)

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China Said to Crack Down on Censorship Protests

People across China have been detained or questioned in recent days by security officers for publicly supporting the journalists at the Southern Weekend newspaper who have been protesting strict censorship, according to a human rights group and online posts discussing the plights of some detainees.

One Taiwanese actress who works on the mainland, Yi Neng Jing, said on her microblog Friday that security officers had asked her to “have tea,” a euphemism for undergoing some form of interrogation. Ms. Yi had supported Southern Weekend with microblog posts.

Chinese Human Rights Defenders said about two dozen people have been detained by security officers since Jan. 8; many were detained outside the Guangzhou headquarters of the parent company of Southern Weekend.

Police officers largely tolerated protests at the headquarters for three days, then began cracking down. On Friday, there was no sign of protesters outside the main gates.

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HP Cloud Ushers in 2013 and GA Compute Service with Reduced Pricing

HP Cloud Services is continuously working to increase efficiency in our datacenters, so we can pass these efforts along to our customers via enhanced enterprise-class service and/or lower prices.  As a result, HP Cloud Services is starting the New Year by permanently lowering the prices on Linux instances of HP Cloud Compute by 12.5% and Object Storage by as much as 25%. 

Furthermore, to celebrate our Compute service’s move to General Availability (GA), we are offering a time-limited 40% discount on all Windows and Linux instances until March 31st, 2013.  We’re doing this to make it even easier for new and existing customers to try our new GA service and perform their initial integration work. You can read more about our differentiated, industry-leading SLA at “Under the Hood of HP Cloud Services SLAs” and about what we’re doing behind the scenes to actually deliver on and surpass our SLAs at “How HP Cloud Services Became Enterprise Class.” 

It’s worth noting that we also recently moved HP Cloud Block Storage to public beta and added several major new features, including bootable persistent volumes and enhancements in volume backup to object storage, as detailed here.  HP Cloud Block Storage is being discounted by 50% while in public beta, so now is the perfect time to give it a test drive if you haven’t already!

You can sign up now to start exploring our enterprise-class cloud.  For ongoing news about our new services, pricing and special offers, follow us on Twitter @hpcloud, subscribe to this blog, and follow our Facebook page.

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Audrey Hepburn: Remembering the Private Legend

By Elizabeth McNeil

01/10/2013 at 07:35 PM EST

Audrey Hepburn with her son, Luca Dotti, in 1985

Audrey Hepburn Childrens Fund

She captivated the world with her doe-eyed beauty, but behind the Givenchy glamour, there was an Audrey Hepburn few people knew.

She thought her nose too big, her feet too large and her neck too long. She loved to shop for groceries (but not clothes), didn't wear makeup at home, never went to the gym and enjoyed two fingers of Scotch every night. 

"She was not this ethereal creature," says Robert Wolders, 76, the Dutch actor who was her companion for the last 13 years of her life. "She was an earthy woman with a ribald sense of humor."

What Hepburn had, adds Wolders, "was more than beauty. It was this extraordinary mystique."

Hepburn left Hollywood at age 34 at the height of her fame, moving into a 1732 farmhouse in Tolochenaz, a small Swiss village, where she found happiness raising two sons and purpose in her charity work for UNICEF. 

Two decades after her death from abdominal cancer at 63 on Jan. 20, 1993, her children and her last love remember the Audrey they adored. 

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Flu season strikes early and, in some places, hard

NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers are turning away visitors or making them wear face masks, and one Pennsylvania hospital set up a tent outside its ER to deal with the feverish patients.

Flu season in the U.S. has struck early and, in many places, hard.

While flu normally doesn't blanket the country until late January or February, it is already widespread in more than 40 states, with about 30 of them reporting some major hot spots. On Thursday, health officials blamed the flu for the deaths of 20 children so far.

Whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.

"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.

The evidence so far points to a moderate season, Schaffner and others say. It looks bad in part because last year was unusually mild and because the main strain of influenza circulating this year tends to make people sicker and really lay them low.

David Smythe of New York City saw it happen to his 50-year-old girlfriend, who has been knocked out for about two weeks. "She's been in bed. She can't even get up," he said.

Also, the flu's early arrival coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." So what people are calling the flu may, in fact, be something else.

"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.

Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it can be hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.

Flu is a major contributor, though, to what's going on.

"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed emergency room saw its busiest day ever last week, with 166 visitors.

The early onslaught has resulted in a spike in hospitalizations. To deal with the influx and protect other patients from getting sick, hospitals are restricting visits from children, requiring family members to wear masks and banning anyone with flu symptoms from maternity wards.

One hospital in Allentown, Pa., set up a tent this week for a steady stream of patients with flu symptoms. But so far "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.

On Wednesday, Boston declared a public health emergency, with the city's hospitals counting about 1,500 emergency room visits since December by people with flu-like symptoms.

All the flu activity has led some to question whether this year's flu shot is working. While health officials are still analyzing the vaccine, early indications are that it's about 60 percent effective, which is in line with what's been seen in other years.

The vaccine is reformulated each year, based on experts' best guess of which strains of the virus will predominate. This year's vaccine is well-matched to what's going around. The government estimates that between a third and half of Americans have gotten the vaccine.

In New York City, 57-year-old Judith Quinones skipped getting a flu shot this season and suffered her worst case of flu-like illness in years. She was laid up for nearly a month with fever and body aches. "I just couldn't function," she said.

But her daughter got the vaccine. "And she got sick twice," Quinones said.

Europe is also suffering an early flu season, though a milder strain predominates there. Flu reports are up, too, in China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo. Britain has seen a surge in cases of norovirus.

On average, about 24,000 Americans die each flu season, according to the CDC. That's an estimate — the agency does not keep a running tally of adult flu deaths each year, only for children. Some state health departments do keep count, and they've reported dozens of flu deaths so far.

Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.

Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.

Flu vaccinations are recommended for everyone 6 months or older. Of the 20 children killed by the flu this season, only two were fully vaccinated.

___

AP Medical Writer Maria Cheng in London contributed to this report.

___

Online:

CDC flu: http://www.cdc.gov/flu/index.htm

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Stock index futures point to flat open

LONDON (Reuters) - Stock index futures indicated a flat-to-slightly lower open on Wall Street on Friday, with some traders citing nervousness ahead of results from financial group Wells Fargo due later in the day.

Futures for the S&P 500 and Nasdaq 100 were flat by 04.30 EST, while futures for the Dow Jones were 0.1 percent lower.

"There's maybe a little bit of nervousness ahead of Wells Fargo's results," said Darren Easton, director of trading at London-based firm Logic Investments.

Boeing Co's 787 Dreamliner jet suffered a cracked cockpit window and an oil leak on separate flights in Japan on Friday - the latest in a series of incidents to test confidence in the sophisticated new aircraft.

Infosys Ltd posted flat third-quarter net profits, beating analyst expectations, as the second-largest Indian software services provider maintained margins despite higher operating costs. It also raised revenue forecast for the full year to end March.

Credit card company American Express Co said it would cut about 5,400 jobs, or 8.5 percent of its workforce, as it restructures its business and pays legal bills.

SAC Capital Advisors expects client withdrawals of at least $1 billion in 2013 as the hedge fund battles intense regulatory scrutiny over insider trading allegations, the Wall Street Journal reported on Friday.

Unsecured creditors of MF Global Holdings Ltd on Thursday proposed a liquidation plan that could pay the brokerage's former customers in full.

Exxon Mobil Corp reported flaring at its 344,500 barrel-per-day (bpd) Beaumont, Texas, refinery, according to a message posted on a community information line.

Tycoon Carlos Slim's retail unit said it plans to relist on the Mexican stock exchange, offering a 15.2 percent stake to raise some $720 million to fund expansion plans, including possible acquisitions.

Supervalu Inc struck a $3.3 billion deal to reduce its burdensome debt by selling five of its supermarket chains to an investor group led by Cerberus Capital Management LP .

The Federal Reserve's policy of zero interest rates and asset purchases is appropriate and perhaps even insufficient, said Narayana Kocherlakota, president of the Minneapolis Fed.

European shares were flat on Friday although the pan-European FTSEurofirst 300 index <.fteu3> remained within sight of two-year highs.

Asian shares and Brent crude futures fell as a pick-up in Chinese inflation prompted profit taking, although an improving outlook for global economies curbed losses.

U.S. stocks rose on Thursday and the S&P 500 <.spx> ended at a fresh five-year high as stronger-than-expected exports from China spurred optimism about global growth prospects.

The Dow Jones industrial average <.dji> gained 80.71 points, or 0.60 percent, to 13,471.22. The Standard & Poor's 500 Index rose 11.10 points, or 0.76 percent, to 1,472.12. The Nasdaq Composite Index <.ixic> added 15.95 points, or 0.51 percent, to 3,121.76.

(Reporting by Sudip Kar-Gupta; Editing by Susan Fenton)

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Top Kurdish Militant Is Among Three Slain in Paris

PARIS — Three Kurdish women, including a founding member of a leading militant group fighting for autonomy in Turkey, were shot to death at a Kurdish institute in central Paris, police officials said on Thursday, potentially complicating fragile efforts to negotiate a cease-fire in the decades-old conflict.

News reports identified one of the women as Sakine Cansiz, a founding member of the Kurdistan Workers’ Party, known by the initials P.K.K. Another was identified as Fidan Dogan, the head of the institute and a representative of the Kurdistan National Committee. The third woman was Leyla Soylemez, a youthful Kurdish activist.

The women’s bodies were discovered shortly before 2 a.m. on Thursday, according to Agnès Thibault-Lecuivre, a spokeswoman for the Paris prosecutor’s office, and the antiterror department of the prosecutor’s office will oversee the investigation.

“No hypothesis can be excluded at this stage" about the motive for the killing, she said, declining to confirm the identities of the victims.

Earlier, a police official said the circumstances of the killings “could lead to the conclusion that this was an execution but inquiries will determine the precise nature of this drama.” Visiting the institute on Thursday, French Interior Minister Manuel Valls called the killings “intolerable” and said they were “without doubt an execution.”

Berivan Akyol, an employee at the Kurdish Institute of Paris, located in the 10th district of the city near the Gare du Nord railroad station, was quoted by Reuters as saying the killings — which opened a new chapter in the often murky annals of Kurdish exile life — were “politically motivated.”

While Kurdish militants blamed Turkey, Turkish officials said the women could have been killed because of feuding within the P.K.K. Huseyin Celik, the deputy chairman of the ruling party in Turkey, said the shootings seemed to be part of “an internal feud,” but offered no evidence to support the claim, The Associated Press reported.

Police officials said a murder investigation had been opened. The bodies and three shell casings were found in a room at the institute. The women were all said to hold Turkish passports.

The P.K.K. has been fighting a bitter guerrilla war against the Turkish authorities for almost three decades to reinforce demands for greater autonomy. The conflict has claimed some 40,000 lives. But, recently, Turkish officials have acknowledged that the authorities in Ankara have negotiated a tentative peace plan with the imprisoned P.K.K. leader, Abdullah Ocalan.

Turkey, the United States and the European Union have labeled the P.K.K. a terrorist organization, but sympathy for the group and its goals remains widespread in many towns in Turkey’s rugged southeast.

Restive Kurdish minorities span a broad region embracing parts of Turkey, Syria, Iraq, Iran and parts of the former Soviet Union.

The killings, which apparently took place Wednesday, inspired hundreds of Kurdish exiles to gather outside the institute, chanting “We are all P.K.K.” and accusing Turkey of assassinating the three women, abetted by the French president, François Hollande, French television reported.

The bodies were first discovered in the early hours of Thursday by Kurdish exiles who had become concerned about the whereabouts of the women.

  The victims had been alone in the building on Wednesday and could not be reached by telephone in the late afternoon, according to Leon Edart, who manages the center. Mr. Edart, speaking to French reporters, suggested the victims may have opened the door to their killer or killers.

An organization called the Federation of Kurdish Associations in France, representing many of the 150,000 Kurdish exiles in the country, said in a statement that the women might have been killed on Wednesday afternoon with weapons equipped with silencers.

The Firat news agency, which is close to the P.K.K., said two of the women had been shot in the head and one in the stomach. Firat quoted Mehmet Ulker, the head of the Kurdish representative group in France as saying” “A couple of colleagues saw blood stains at the door. When they broke the door open and entered they saw the three women had been executed.”

Most of the Kurdish exiles in France are from Turkey. Their presence dates to the mid-1960s when migrant workers from Turkey began arriving in France.

The killings came against a complex political backdrop after the Turkish government opened talks with the political wing of the P.K.K. in Oslo last year. The negotiations faltered after a recent surge of violence in southeastern Turkey that prompted complaints from nationalist Turks that the authorities should not talk to the guerrilla fighters.

In the absence of any clear-cut military outcome, democracy advocates in Turkey have been pressing for a political settlement which would give greater rights to the Kurds, who account for around 15 million of Turkey’s 74 million population.

In a speech on Wednesday, Prime Minister Recep Tayyip Erdogan said the negotiations were being conducted by senior intelligence officials. Mr. Ocalan, the P.K.K. leader who has been imprisoned since 1999, still has a powerful following among the rebels. He has been denied a role in earlier political talks. But, analysts say, his participation in the current negotiations, authorized by the state, has enhanced the prospects of a breakthrough.

Turkish news reports have said the government wants the rebels to lay down their arms without preconditions and send fighters with a record of violence into exile in Europe, leaving other Kurdish representatives to join Turkish political life. But analysts say any further negotiations could be sabotaged by opponents if it appeared that talks were making firm progress.

Scott Sayare reported from Paris, Alan Cowell from London and Sebnem Arsu from Istanbul.

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Could Alex Jones’s “revolution” actually happen?

Piers Morgan had it easy. Radio show host and author Alex Jones threatened the rest of us with a ”revolution” if the government decides to confiscate guns from the homes and glove compartments of law-abiding Americans. It’s almost too easy to dismiss Jones as a fringe figure, especially since fringe ideas make their way into the mainstream with (exciting? alarming?) frequency these days. So let’s take him seriously.

Let’s accept his premise. Actually, let’s dismiss it first but then turn around and accept it for the sake of argument. The government has not the means nor the mechanism nor the credibility to confiscate 100,000 guns, much less 600,000,000. And those in the government doing the confiscating would be neighbors and relatives of the confiscatory victims: police officers, national guard members, Army reservists. Of course, Jones might say that their intent is bad enough. But “they” — the Obama administration, I assume — have no such intentions, and never did.

But OK. Let’s say that the government tries to confiscate guns and “the people” attempt to revolt.  No doubt that civil disobedience can spring up rather spontaneously and even be organized very quickly, but if rioting were to somehow break out in American cities, it would be isolated and theoretically containable. Organizing a “revolt” would require extensive planning, including the massive transportation of citizens from their homes to wherever the rally points were, a communications infrastructure, and leaders. The same Open Source culture that would make it difficult for the government to plan a confiscation in secret makes it just as unlikely for citizens to plan a feasible response to that confiscation in secret.

One of Jones’s obsessions, which, I confess, I share, is the militarization of the American homeland, and he is not promulgating a conspiracy here. The military has expanded its presence on American soil, and crucially, has expanded the way it is organized to respond to mass contingency events of any kind, including natural disasters and rioting. The U.S. Northern Command does receive intelligence briefings about domestic disturbances from the FBI and DHS, so commanders would be somewhat prepared to deploy troops. Thousands would come from the standing Army, but the bulk would be drawn from state National Guard detachments. It is exceedingly difficult to picture weekend warriors following blind orders en masse to detain or harm U.S. citizens when local police resources are stretched. The government has the power of command and control, but the people have the power of fellow-feeling. The government’s response to any real revolt would probably be quite restrained. There’d be too much attention paid to every movement of every tank to act harshly. The strategy to contain any “revolt” might therefore depend on a period of people letting out their energies and then returning to their normal business. 

Ah, but what if the government controls the communication nodes?  Well, corporations do; I assume Jones would have them immediately bend to a secret executive order shutting down serves and clouds and services like Twitter, but even if corporations agreed to do this, together, it would take days to get even a fraction of the telecom infrastructure offline. Maybe the government would order a mass power outage. But that’s why so many Americans have generators in the first place!  Although government “boards” comprising major telecom and infrastructure executives do exist, the most they’ve ever contemplated doing is to shut down a narrow slice of an infected communications node. These days, they’re focused on the cyber threat.  In the early days of civil defense planning, when there were a few television networks an AT&T had its monopoly, the threat of a government takeover of TV, radio and telephones was technically feasible. Today it is not. Actually, it does not make sense. What’s turned on really cannot be turned off.

But wait. if Jones’s “revolution” is to succeed, he needs to take over the government, because he’d need to dominate communications as well, unless he assumes that his movement would be organic and immune to arguments from elected officials asking for stability and calm.

An objective of anyone who wants to take over the government would be a seizure of the Emergency Broadcast System, which allows the President to speak to the nation through almost any mechanism of communication at any time. The EBS lives at Mt. Weather, the massive FEMA bunker in Virginia, but it can be activated and controlled from at least a dozen other places, including the briefcase of the Emergency Actions officer who travels with the President.  A coordinated violent action to seize control of this key portal would require an incredible amount of prior planning.

Assuming even that the government’s response to isolated-turned-mass rioting is uneven, the President would be able to address Americans anytime he wants. In theory, Jones’s followers could try to take over every broadcast entity in America, or could try and jam the broadcasts using sophisticated electronic warfare technology available to the military, but once again, the practicalities are not possible.

Because there will be no revolt over gun control, because there will not be and cannot be a mass confiscation of guns, playing with these ideas is fanciful and fodder for a sequel to Seven Days in May. Heck, we haven’t even addressed the FEMA concentration camps (which don’t exist).  But that isn’t to say that nothing discussed above will ever be relevant. It is much easier to imagine a small-scale revolt, a series of pre-planned violent protests against the powers that be, perhaps because the political system seems so non-responsive to the worries of people who listen to Alex Jones.  It would not take much to make Americans nervous about the government’s ability to restore law and order. And that frission itself is probably the most unknowable of all these factors.

Patriotic citizens aren’t supposed to speculate about these extremely unlikely events, but the government certainly thinks about them. So maybe we should too.

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Sandra Bullock Honored at People's Choice Awards for New Orleans Support

By Alison Schwartz

01/09/2013 at 10:45 PM EST

Sandra Bullock at the People's Choice Awards

Jason Merritt/Getty

Sandra Bullock took home big honors for her work in the Big Easy Wednesday night.

The People's Choice Awards crowned the Oscar-winning actress the favorite humanitarian for her career-spanning philanthropic efforts, including her dedication to New Orleans's Warren Easton Charter High School

"I'm not at all being modest when I say I'm not doing anything compared to what they do on a daily basis," Bullock, 48, told the crowd gathered at Los Angeles's Nokia Theatre.

Just six months after Hurricane Katrina hit in 2005, the actress showed her support by adopting the school, which sustained $4 million in damages during the storm. She donated hundreds of thousands of dollars for renovations, telling PEOPLE years later that she "felt such a profound need to do something for them."

Her generosity helped the charter school – the first public high school for boys in Louisiana – afford renovations, new band uniforms, athletic equipment and a new health clinic in a city that's close to her heart. After all, she adopted her son, Louis, from New Orleans in 2010 and also has a home in the Garden District.

She pointed to the tireless dedication of the school's students, teachers and tough principal. "I've seen her," she joked. "Yeah, you don't want to go into that office."

Bullock then gave a shout-out to her son, who was sick as home, she said.

"[The students] compete, but they never cut each other down," she added. "And all that happens not because it's easy, but because they do not allow themselves any other option than to succeed."

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Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

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